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Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 363-370 doi: 10.1007/s11684-010-0210-7

Abstract: as retinoic acid receptor-alpha (RARα), acute myeloid leukemia 1 (AML1), CAAT/enhancer-binding proteinUbiquitin-mediated protein degradation represents a critical mechanism in regulating the cellular levelsThus, targeting protein degradation has been emerging as an important strategy to conquer malignant diseasesIn this review, we will summarize the recent advances in the understanding of the roles of protein degradation

Keywords： protein degradation     leukemia     chemical biology     transcription factors     oncoprotein    

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Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 97-104 doi: 10.15302/J-FASE-2018248

Abstract: The N-end rule pathway of protein degradation is also directly linked to NLR stability.

Keywords： E3 ubiquitin ligase     degradation     nucleotide-binding leucine-rich repeat receptor     plant immunity     proteasome     protein stability     ubiquitination    

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Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering Article

Yuan Ma, Mingdong Yao, Bingzhi Li, Mingzhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan

Engineering 2018, Volume 4, Issue 6,   Pages 888-893 doi: 10.1016/j.eng.2018.09.007

Abstract: around the substrate-binding groove in order to create novel high-efficiency PETase mutants through proteinThe I179F mutant showed the highest activity, with the degradation rate of a PET film reaching 22.5 mgThus, this study has created enhanced artificial PETase enzymes through the rational protein engineering

Keywords： Polyesterase     PET degradation     Cell-free protein synthesis     Polyester     PETase    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: The mammalian target of rapamycin (mTOR) critically regulates several essential biological functions, such as cell growth, metabolism, survival, and immune response by forming two important complexes, namely, mTOR complex 1 (mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has been considered an attractive cancer therapeutic target. Great efforts have been made to develop efficacious mTOR inhibitors, particularly mTOR kinase inhibitors, which suppress mTORC1 and mTORC2; however, major success has not been achieved. With the strong scientific rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapy in clinics. Beyond early findings on induced activation of PI3K/Akt, MEK/ERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapy, recent findings on the essential role of GSK3 in mediating cancer cell response to mTOR inhibitors and mTORC1 inhibition-induced upregulation of PD-L1 in cancer cells may provide some explanations. These new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy. Further elucidation of the biology of complicated mTOR networks may bring us the hope to develop effective therapeutic strategies with mTOR inhibitors against cancer.

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Influence of construction-induced damage on the degradation of freeze–thawed lightweight cellular concrete

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 781-792 doi: 10.1007/s11709-021-0733-9

Abstract: construction of lightweight cellular concrete (LCC), material damage frequently occurs, causing the degradation

Keywords： lightweight cellular concrete     construction-induced damage     freeze-thaw action     microstructure     degradation    

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Efficient degradation of orange II by ZnMn

Qingzhuo Ni, Hao Cheng, Jianfeng Ma, Yong Kong, Sridhar Komarneni

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 6,   Pages 956-966 doi: 10.1007/s11705-019-1907-z

Abstract: Its catalytic activity has been investigated for the degradation of orange II dye using three differentThe last system exhibits the maximum degradation efficiency of 90%, much higher than the photocatalysisFurthermore, the potential degradation mechanisms applicable to the three systems are discussed withactive species such as Mn(III), O , h , e , SO and HO are proposed to be responsible for the excellent degradation

Keywords： ZnMn2O4     photo-chemical catalysis     bisulfite     dye degradation    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 279-287 doi: 10.15302/J-FASE-2019267

Abstract: Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing qualityBased on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein.

Keywords： wheat gluten     consensus motifs     disulfide bonds     SDS-unextractable polymeric protein     glutenins     gliadins     processing quality     storage protein    

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Promotive effect of pyridine on indole degradation by activated sludge under anoxic conditions

LI Yongmei, GU Guowei, LI Wenshu

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 4,   Pages 493-497 doi: 10.1007/s11783-007-0079-0

Abstract: Batch experiments were carried out to investigate the promotive effect of pyridine on indole degradation

Keywords： wastewater treatment     coal-coking wastewater     promotive     degradation    

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Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8,   Pages 1131-1139 doi: 10.1007/s11705-023-2321-0

Abstract: modification of silk fabric by impregnation with riboflavin sodium phosphate was proposed, such that protein

Keywords： biomass     riboflavin sodium phosphate     silk protein     multifunctional modification     flame retardant    

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anchored alginate/poly(acrylic acid/acrylamide) double-network hydrogel composites for efficient catalytic degradation

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 893-905 doi: 10.1007/s11705-022-2290-8

Abstract: In the tap water system and simulated seawater system, the degradation time of p-nitrophenol atMoreover, the catalyst exhibited outstanding performance in the degradation experiment of four typical

Keywords： double-network hydrogel     dye degradation     silver nanoparticles     alginate    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased proteinThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Sustainable wood-based nanotechnologies for photocatalytic degradation of organic contaminants in aquatic

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1346-6

Abstract:

•Wood and its reassemblies are ideal substrates to develop novel photocatalysts.

Keywords： Wood     Nanocatalysts     Photodegradation     Organic contaminants     Composites    

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Title Author Date Type Operation

Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Journal Article

Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Journal Article

Rao Yu: Small Molecule Targeted Protein Degradation Technology and Application (2022-12-15)

22 Dec 2022

Conference Videos

Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering

Yuan Ma, Mingdong Yao, Bingzhi Li, Mingzhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

Influence of construction-induced damage on the degradation of freeze–thawed lightweight cellular concrete

Journal Article

Efficient degradation of orange II by ZnMn

Qingzhuo Ni, Hao Cheng, Jianfeng Ma, Yong Kong, Sridhar Komarneni

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Journal Article

Promotive effect of pyridine on indole degradation by activated sludge under anoxic conditions

LI Yongmei, GU Guowei, LI Wenshu

Journal Article

Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Journal Article

anchored alginate/poly(acrylic acid/acrylamide) double-network hydrogel composites for efficient catalytic degradation

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Sustainable wood-based nanotechnologies for photocatalytic degradation of organic contaminants in aquatic

Journal Article